The EU MCSA VIRTUOUS project aims to create a virtual tongue through an integrated computational framework able to screen food for natural ligands targeting taste receptors. VIRTUOUS integrates drug discovery techniques, big-data and machine learning algorithms to predict the organoleptic profile of Mediterranean ingredients based on their chemical composition. Recent developments in the VIRTUOUS project will be presented in the workshop, ranging from new algorithms for advanced modelling simulation, machine learning tools to identify the most relevant descriptors affecting compounds’ taste, and standardized procedures for sensory analysis of virgin olive oils. New results on application of artificial intelligence for quality assessment of extra-virgin olive oil from fluorescence spectrum will be shown. Finally, a first DEMO of the Virtuous platform will be presented